منابع مشابه
Knocking out the Argonautes
Argonaute proteins are key players in gene silencing involving small RNAs. In this issue, Yigit et al. (2006) report a comprehensive study of Argonautes in the worm that places many of the 27 family members into a complex gene-silencing network.
متن کامل“Knocking out” a Neural Circuit
Although the visual system occupies nearly half of the mammalian brain, we still do not completely understand its first synaptic stage. One reason is that the dendrites postsynaptic to photoreceptors comprise such a maze of fine processes that doubt remains whether all the second order circuits have been identified—even after 4 decades of electron microscopy. Now advanced functional methods app...
متن کاملKainate receptors: knocking out plasticity.
There is increasing evidence that kainate receptors contribute to both postsynaptic and presynaptic signaling. Studies of knockout mice have played a pivotal role in defining the functions of kainate receptors, including a recent study that implicates kainate receptors in frequency-dependent facilitation and long-term potentiation of hippocampal mossy fiber synapses.
متن کاملKnocking out the door to tunicamycin entry.
P rotein homeostasis within the endoplasmic reticulum (ER) is essential for cell viability, and its misregulation is implicated in a growing number of diseases, including Alzheimer’s disease, diabetes, and cancer (1–3). Consequently, the pharmacological manipulation of this pathway is of broad scientific and clinical interest. A variety of drugs have been used to model specific types of stresse...
متن کاملKnocking Out P k -free Graphs
A parallel knock-out scheme for a graph proceeds in rounds in each of which each surviving vertex eliminates one of its surviving neighbours. A graph is KO-reducible if there exists such a scheme that eliminates every vertex in the graph. The Parallel Knock-Out problem is to decide whether a graph G is KO-reducible. This problem is known to be NP-complete and has been studied for several graph ...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2004
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200324338